As the result, HSP60 was down-regulated in bronchial adenocarcinoma, vesical transitional cell carcinoma and carcinosarcoma18, 19, 20, 21 whereas the high HSP60 expression was presented in cervical cancer, prostate cancer, breast cancer and GBM22, 23, 24, 25. This evidence concerns the gene HSPD1 and Familial prostate cancer.