TCF7L2 and cancer: The WNT signalling pathway was activated in 93 % of non-hypermutated and 97 % of hypermutated cancers, involving biallelic inactivation of APC or activation of CTNNB1 in over 80 % of tumours, together with changes to many other genes involved in regulation of the WNT pathway (TCF7L2, DKK, AXIN2, FBXW7, ARID1A, FAM123B, FZD10 and SOX9).