SMAD4 and neoplasm: SCNA patterns in non-hypermutated MSS tumours confirmed the previously well-documented [5] chromosomal arm-level changes of significant gains of 1q, 7p, 7q, 8p, 8q, 12q, 13q, 19q and 20p, and significant deletions of 1p, 4q, 5q, 8p, 14q, 15q, 17p (includes TP53) and 17q, 18q (includes SMAD4), 20p and 22q.