The second group (around ∼13–16 % of sporadic CRC) are hypermutated and show microsatellite instability (MSI) due to defective DNA mismatch repair (MMR), often associated with wild-type TP53 and a near-diploid pattern of chromosomal instability (Fig. 1) [6]. The gene discussed is TP53; the disease is colorectal carcinoma.