The WNT signalling pathway was activated in 93 % of non-hypermutated and 97 % of hypermutated cancers, involving biallelic inactivation of APC or activation of CTNNB1 in over 80 % of tumours, together with changes to many other genes involved in regulation of the WNT pathway (TCF7L2, DKK, AXIN2, FBXW7, ARID1A, FAM123B, FZD10 and SOX9). This evidence concerns the gene APC and neoplasm.