OGG1 and major depressive disorder: Moreover, the heterozygote of c.*589G>C–NEIL decreased the risk of depression in cases with lower DRE as well as lower oxidative DNA damage recognized by either Nth or hOGG1 (Supplementary Tables 2, 6, and 8), while the C/C homozygote increased this risk in patients with lower oxidative DNA damage recognized by Nth (Supplementary Table 6).