In normal rats, PRR gene delivery into the heart induces deleterious myocardial fibrosis associated with the increased expression of various pro-fibrotic genes, such as TGFβ1, CTGF, collagen 1α1, plasminogen activator inhibitor-1, and fibronectin-1, indicating that PRR plays a critical role in hearts undergoing the fibrotic remodeling process (Moilanen et al. 2012). Here, ATP6AP2 is linked to Myocardial fibrosis.