TERT and cancer: Some cancers, such as melanoma, pleomorphic dermal sarcoma, myxoid liposarcoma, glioma, urothelial cell carcinoma, carcinoma of the skin and liver cancer, have the highest frequencies of TERT promoter mutations, while low frequencies were noted in gastric cancer, pancreatic cancer, non-small-cell lung cancer and gastrointestinal stromal tumors [6, 45, 48].