Indeed, these patients, who were not undernourished, had similar levels of leptin than healthy subjects and had high plasma concentrations of active ghrelin, with fasting and postprandial active ghrelin concentrations higher in jejuno-colonic SBS patients than in control individuals. The gene discussed is GHRL; the disease is macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss.