The calculated total area under the curve (AUC), reflecting the absolute levels of ghrelin and the post-prandial response, was significantly greater (by a factor of two, P < 0.05 vs controls) in SBS patients (Supplemental Figure S2B). This evidence concerns the gene GHRL and macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss.