GHRL and macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss: In conclusion, we demonstrate that SBS is associated with an increase in fasting plasma ghrelin concentration and an induction of orexigenic signals in the hypothalamus, in a rat model with jejuno-colonic anastomosis and that post-prandial ghrelin inhibition is impaired in SBS patients.