CXCL12 and cancer: To investigate the possible role of fibroblast-secreted SDF1 in the SRF-enhanced migration of cancer cells, the conditioned medium from SRF-overexpressing fibroblasts (CCD18Co or NIH3T3) was treated with normal rabbit IgG or an anti-SDF1 neutralizing antibody (final conc. 5.0 μg/mL) and then used to co-culture MKN45 cells.