Our study shows that (a) aberrant expression of PAK7 is significantly associated with more aggressive tumors, advanced clinical stage, LNM, and advanced tumor stage in colon cancer; (b) the PAK7-positive staining of colon cancer cells could be used to identify a highly increased risk of metastasis in patients after surgery, which might serve as a valuable prognostic maker (c) PAK7 promotes the migration and invasion of colon cancer by affecting ENT induction in vitro and in vivo. The gene discussed is PAK5; the disease is malignant colon neoplasm.