PAK5 and neoplasm: Increased PAK7 expression was significantly correlated with the depth of tumor invasion (pT stage, P = 0.004), LNM (pN stage, P < 0.001), distant metastasis (M stage, P = 0.034), histologic grade (P < 0.001), and advanced AJCC cancer stage (P < 0.001) (Table 2).