They have successfully identified numerous single-nucleotide polymorphisms (SNPs) that might play a role in the pathophysiology of lung cancer, such as loci located in chromosomal regions 15q (nicotinic acetylcholine receptor subunits: CHRNA3, CHRNA5), 5p (TERT-CLPTM1L) and 6p (BAT3-MSH5). This evidence concerns the gene CHRNA5 and lung cancer.