Hence, the endocannabinoid system as a target of exocannabinoids is a candidate to produce schizophrenia by inducing NMDAR hypofunction and/or altering NMDAR-GPCR cross-regulation [3, 39], while in humans the HINT1 and σ1R genes have also been implicated in schizophrenia [114, 115, 116]. The gene discussed is HINT1; the disease is schizophrenia.