Since our aim is to analyze these neural dysfunctions from a new perspective, that of the control exerted by the CB1R via HINT1/σ1R on NMDAR function, we will describe just a few promising findings regarding the effects of CBD on schizophrenia, and the effects of CBD combined with cannabinoids in the treatment of NMDAR convulsive episodes. This evidence concerns the gene CNR1 and schizophrenia.