Since our aim is to analyze these neural dysfunctions from a new perspective, that of the control exerted by the CB1R via HINT1/σ1R on NMDAR function, we will describe just a few promising findings regarding the effects of CBD on schizophrenia, and the effects of CBD combined with cannabinoids in the treatment of NMDAR convulsive episodes. The gene discussed is HINT1; the disease is schizophrenia.