Parenthetically, YY1 in this collaboration with JARID2 can recruit EZH2 and HDAC 1 to the promoter region leading to a block in differentiation, partially via the downregulation of miR-29b2 and miR-29c and by inhibiting MyoD, favoring rhabdomyosarcoma cell proliferation over differentiation [11–17, 28]. This evidence concerns the gene YY1 and rhabdomyosarcoma.