Intriguingly, our study revealed higher expression levels of FZD2, LRP6 and cyclin D1 in MYCN-amplified SK-N-DZ NB cells and tumors, while β-catenin (both total and active) and MYC were higher expressed in MYCN-unamplified SK-N-AS cells and tumors. This evidence concerns the gene LRP6 and neuroblastoma.