On the other hand, treatment of NB cells with recombinant Wnt3a increased SK-N-AS and SK-N-DZ cell proliferation (P < 0.001 and P < 0.04, respectively), whereas Wnt5a stimulation increased cellular proliferation of SK-N-AS (P < 0.001) but not SK-N-DZ cells as compared with unstimulated cells (Figure 3A). The gene discussed is WNT3A; the disease is neuroblastoma.