Abnormal expression of histone methyltransferases (HMTs), including Mixed-Lineage Leukemia 2 (MLL2), Mixed-Lineage Leukemia 3 (MLL3), nuclear receptor binding SET domain protein 1 (NSD1) [4], enhancer of zeste homolog 2 (EZH2) [5] or SET and MYND domain containing 3 (SMYD3) [6], was reported in PCa. Here, NSD1 is linked to posterior cortical atrophy.