However, statistical significance between COX-2 expression and high risk of lymph node metastasis (OR, 1.28; 95% CI, 1.03–1.60; p = 0.027; Figure 3) and advanced TNM stage were found (OR, 1.33; 95% CI, 1.06–1.66; p = 0.015; Figure 4). This evidence concerns the gene PTGS2 and metastatic malignant neoplasm in the lymph nodes.