Moreover this paper also reported loss of p27 expression in human type 1 gastric neuroendocrine tumors associated with atrophic gastritis and showed similar alterations in p27 distribution (by immunocytofluorescence as well as subcellular fractionation) in the CCK2R expressing AGS-E cell line following gastrin treatment [59]. Here, CCKBR is linked to chronic atrophic gastritis.