Our integrative analysis of the miRNA-mRNA interplay as well as of the expression patterns of potential miRNA-miRNA pairs based on the expression profiles in CRC tissues and matched adjacent non-tumor mucosa underscores the pivotal role that the miRNA-clock genes axis plays in colorectal tumorigenesis and improves our understanding of the miRNA-mRNA regulatory networks deregulated in this common malignancy. The gene discussed is CLOCK; the disease is colorectal carcinoma.