CDH1 and breast neoplasm: While down-regulation of AKT1 failed to exert any effect at either time point (data not shown), down-regulation of AKT2, which promotes breast tumor growth and metastasis [18], resulted in decreased amounts of Slug, Twist and N-cadherin, and increased amounts of E-cadherin and β-catenin, with a more pronounced effect at 72 hours (Figure 1C).