RIPK3 and obesity due to melanocortin 4 receptor deficiency: As shown in Fig. 3c, RIPK3 showed a similar upregulation of RIPK3 in epiWAT on conventional HFD feeding, as seen in CD-HFD-fed mice, suggesting that, independent of choline deficiency, obesity represents a general stimulator for RIPK3 overexpression in epiWAT.