As demonstrated in Figure 8C and 8D, Stimulation with IGF-1 for 24 h significantly increased the expression levels of STAT3-targeted genes, including survivin, BCL-XL, and MCL-1, while IT pretreatment for 2 h markedly decreased IGF-1-induced survivin, BCL-XL, and MCL-1 expression in human melanoma A375S and A2058 cells. The gene discussed is STAT3; the disease is melanoma.