BRAF and melanoma: IT treatment (2.5, 5, 10, 20, 40 and 80 μM; 24, 48, and 72 h) significantly induced cytotoxicity to human melanoma A375S (parental cells, sensitive to BRAF inhibitor), A375R (resistant to BRAF inhibitor), A2058, and MEWO cells in a time- and dose-dependent manner.