The 89-gene signature consists of a number of hypoxia and inflammation-related genes such as AKR1C3 [44], PTX3, PLAT [45] and IGFBP2 [46], showing that these two inseparable hallmarks are involved in tumor progression [47, 48] and play significant roles in glioma pathogenesis. This evidence concerns the gene PTX3 and central nervous system cancer.