shRNA-mediated knockdown of lnc-JPH1-7 reduced the expression of EMT-promoting genes for N-cadherin (CDH-2) and Snail (SNAI1), as well as anti-apoptotic gene XIAP, in HNSCC cell lines UMSCC-10B and HN-30 (Figure 4A). The gene discussed is SNAI1; the disease is head and neck squamous cell carcinoma.