To investigate the role of piR- 34736 in HNSCC malignancy, we suppressed piR- 34736 expression in the UMSCC- 10B and HN-30 cell lines, resulting in significantly increased Bax/Bcl2 ratio and repression of EMT-mediator Vimentin (VIM) (Figure 4C). This evidence concerns the gene BCL2 and head and neck squamous cell carcinoma.