This result was unexpected because, in a previous study, we supposed that GPR30 can be involved in exemestane response since it acted by cAMP modulation and estrogens and antiestrogens signal via GPR30 was mediated by stimulation of cAMP [11, 21] To verify this hypothesis, we explored the GPR30 expression in normal and mesothelioma cell lines by western blot and conducted in vitro experiments to test the GP30 function with G15, its antagonist. Here, GPER1 is linked to mesothelioma.