Together with our previous study, our findings in OSCC cells suggest that a tumor's PON2 level reflects the cancer cells resistance against irradiation and that PON2 expression may have a predictive value whether or not a post-therapy relapse may occur – in a manner similar to what others showed for PON2 levels in pediatric acute lymphoblastic leukemia [28]. Here, PON2 is linked to acute lymphoblastic leukemia.