Wnt signaling via the canonical and non-canonical pathway was identified to regulate hematopoietic ontogeny in fetal and adult hematopoiesis: Overexpression of Wnt proteins and defective GSK-3β were found to be associated with pre-B-cell leukemia and chronic myeloid leukemia (CML) respectively, while in acute myeloid leukemia (AML) overexpression of β-cat is associated with a poor prognosis [7], [8], [9], [10]. This evidence concerns the gene GSK3B and chronic myelogenous leukemia, BCR-ABL1 positive.