EP300 and glioblastoma: The thiazole-based synthetic compound, BF1 (1-(4-(4- chlorophenyl) thiazol-2-yl)-2-(propan-2-ylidene) hydrazine) can inhibit p300 and GCN5 in vitro, and when tested in both neuroblastoma and glioblastoma cell lines, it shows a global reduction in histone H3 and specific acetylation at K18 [151].