The binding of Ikaros at the promoter regions of IL7R and SH2B3 was further confirmed by qChIP and we found that Ikaros significantly bound to their promoter regions in Nalm6 and Ramos, malignant B cell lines (Figure 3C and 3D) and in primary cells from B-ALL patients (Figure 3E and 3F) but not in Molt 4 and U937 cells (T cell and myeloid leukemias, respectively). This evidence concerns the gene SH2B3 and acute lymphoblastic leukemia.