SH2B3 and precursor B-cell acute lymphoblastic leukemia: Results show that the TBB induces a strong binding of Ikaros (Figure 7A) and enrichment of histone H3 trimethylation at lysine 4 (H3K4me3) (Figure 7B) in the promoter region of SH2B3 in Nalm6 cells, and also in primary B-ALL cells (Figure 7C and 7D).