MET and renal cell carcinoma: To investigate whether c-MET has a role in the bone metastatic process induced by RCC stem cells, we treated mice with JNJ-38877605 (hereafter referred to as JNJ), a highly specific c-MET inhibitor, which was not toxic on RCC stem cell culture in vitro, also at high concentrations as demonstrated by the citoxicity assay (Figure S2).