LAMP2 and Danon disease: Autophagy-induced by various stresses has been gradually determined, any barriers in the autophagic process are likely to lead to dysfunction of mitochondrial autophagy, for instance suppression of constitutive cardiomyocyte autophagy, or impairment of late stages of autophagy in the absence of lysosome associated membrane protein-2 (LAMP2) in patients with Danon disease and in mice with LAMP-2 ablation, resulting in cardiomyopathy.