To determine whether NLRP3 inflammasome activation occurs in HSCs from the liver of mice infected with Schistosoma J. and whether this inflammasome activation is implicated in the development of schistosomiasis-associated liver fibrosis (SSLF), we first produced a SSLF mouse model with Schistosoma J. cercariae. Here, NLRP3 is linked to Hepatic fibrosis.