NUB1 and dementia: NUB1, a negative regulator of ubiquitin-like proteins, was shown to enhance proteasomal degradation of the aSyn-interacting protein synphilin-1[51], to enhance tau phosphorylation and aggregation[52], and to co-localize with presynaptic PK-resistant aSyn in the brains of patients with dementia with LB [53].