The mRNA levels of Wnt receptors Fzd5 and Fzd8 were increased in RCC when compared to the normal kidney tissue, which was followed by the increase of their downstream target cyclin D1, suggesting that Fzd5 and Fzd8 may have a role as biomarkers in RCC [53]. The gene discussed is CCND1; the disease is renal cell carcinoma.