As expected, the present study showed that the results marked hypertension (increased systolic blood pressure and protein levels of ET-1), obese states (increased body weight, fat weight, adipocyte size and plasma levels of leptin), hyperlipidemia (increased plasma total cholesterol, triglycerides and LDL-cholesterol), impaired glucose tolerance (decreased protein levels of IRS-1 and Glut4), fatty liver (increased liver weight and fat accumulation) and vascular remodeling (increased endothelial dysfunction and adhesion molecules) through eight weeks of an HF diet. Here, IRS1 is linked to endothelial dysfunction.