INS and obesity due to melanocortin 4 receptor deficiency: For example, miR-26a targeting several key regulators of hepatic metabolism and insulin signaling, such as GSK3β, PKCδ/θ, ACSL3/4, PCK1 and TCF7L2, ameliorates the obesity-induced metabolic complications by improving the insulin sensitivity and decreasing both of the hepatic glucose production and the fatty acid synthesis in mice fed with a high-fat diet [28].