Although the function of Wnt11 and Wnt6 in liver fibrosis was unknown, Wnt11 was shown to enhance the expression of mesenchymal markers, such as Zeb1, Snail1, Pai1 and α-SMA, in response to the TGF-β signaling in renal fibrosis [55], and Wnt6 was reported to be downregulated during renal fibrogenesis [56]. This evidence concerns the gene SERPINE1 and Hepatic fibrosis.