The collected data have indicated (1) an increase of urinary AQP2 in patients with essential hypertension receiving saline infusion [51], congestive heart failure [52], SIADH [53], liver cirrhosis [54], and pregnancy [55]; and (2) a decrease of urinary AQP2 in patients with DI [10,56]. This evidence concerns the gene AQP2 and cirrhosis of liver.