Metastasis, a complex, multistep process that involves cytoskeleton remodeling, matrix metalloproteinases (MMPs), homing receptors and their ligands, intracellular signaling pathways (TGFβ and TGFβ/c-Met) and angiogenesis, is a hallmark of malignant tumors [218,219]. The gene discussed is TGFB1; the disease is cancer.