AKT1 and neoplasm: Another study showed that ectopic expression of the tumor suppressor miR-375 reduced cell viability in GC cells through the proliferative PI3K/Akt pathway (by targeting JAK2 and PDK1) and the anti-apoptotic NF-κB signaling pathway (by targeting the anti-apoptotic protein 14-3-3ζ) [86,174,175].