The crude extract of Pien Tze Huang was also reported to induce the apoptosis of human osteosarcoma MG63 cells by the activation of caspase cascades and the alteration of apoptotic mediators bcl-2 and bax expression, further demonstrating the important roles of Bcl-2, Bax protein, and caspase cascades in the apoptosis of tumor cells [20]. The gene discussed is BCL2; the disease is osteosarcoma.