Likewise, downregulation of GalNAcT2 in hepatocellular carcinoma (HCC) cells promoted cell growth, migration, and invasion in vitro and in vivo by modulating the O-glycan pattern on EGFR, resulting in EGFR activation by dimerization, and phosphorylation of downstream signaling proteins [34]. This evidence concerns the gene GALNT2 and hepatocellular carcinoma.