However, patient-derived primary human AML cells (we used primary AML-PB001F mononuclear blasts obtained from leukaemia patients) do not differ from the two ML cell lines in respect of the easily detectable LPHN1 expression and its upregulation in response to mTOR stimuli (LPS, SCF and anti-Tim-3). This evidence concerns the gene ADGRL1 and acute myeloid leukemia.