The expression level of CAR10, EGFR, and YB-1 was tested in the tumor tissues by qRT-PCR or Western blot, and the results showed that in the lungs of the mice inoculated with shCAR10-A549-luciferase cells, the expression of CAR10 (Figure 7F), EGFR and YB-1 (Figure 7G) was markedly lower than the control group. Here, ADAM12 is linked to neoplasm.