Our recent studies have identified that microRNA-1291 (miR-1291), a less studied miRNA that is generated from small nucleolar RNA H/ACA box 34 (SNORA34) in pancreatic cancer PANC-1 cells, is able to increase intracellular drug accumulation and chemosensitivity through targeting of efflux transporter namely multidrug resistance-associated protein 1 (MRP1/ABCC1) [30, 31]. The gene discussed is ABCC1; the disease is pancreatic neoplasm.