In an effort to understand the generality of our findings, we generated a series of affinity-reduced variants of the anti-EGFR GA201 mAb [28] and also reconstructed the anti-HER2 antibody sequences depicted by Tang et al and evaluated their capacity to elicit ADCC in vitro against various tumor cell lines expressing different levels of target antigen. This evidence concerns the gene ERBB2 and neoplasm.