The robust tumorigenic drive of DU145 prostate cancer cells has been associated with constitutive over-expression of microsomal prostaglandin E synthase-1 (mPGES-1) and higher output of PGE-2 [7], which, in turn, impinges on several pro-tumorigenic pathways such as EGFR and Wnt [8–13]. Here, PTGES is linked to Familial prostate cancer.