Finally, silencing of Dicer in DU145 mPGES-1+/+ cells increased HUVEC-mediated sprouting in the co-cultured model (Supplementary Figure S7D, panel B, and C), indicating that mPGES-1/PGE-2 promotes activation of endothelial cells in prostate cancer cells by reducing Dicer, miR-15a and miR-186 expression, thus promoting VEGF secretion. The gene discussed is VEGFA; the disease is Familial prostate cancer.