miR-186 mimic treatment (3 μg/mouse) of DU145 and PC3 mPGES-1+/+ mouse xenograft led to a significant reduction in mPGES-1+/+ tumor size compared to control tumors (Figure 6A), showed lower vessel density and smaller luminal size (Figure 6B left and right graph, respectively), as well as a comparable reduction in VEGF protein expression (Figure 6C and 6D). Here, VEGFA is linked to neoplasm.