ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive: Not surprisingly, it exhibited strong anti-proliferative effect against BCR-ABL dependent CML cell lines such as K562 (GI50: 0.056 μM), KU812 (GI50: 0.057 μM) and MEG-01 (GI50: 0.018 μM) (Table 2).