CHMFL-074 displayed strong anti-proliferative efficacy against BCR-ABL–driven CML cell lines such as K562 (GI50: 56 nM), MEG-01 (GI50: 18 nM) and KU812 (GI50: 57 nM). The gene discussed is ABL1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.