The first BCR-ABL inhibitor, Imatinib (Gleevec [5]), as the seminal target therapy for the CML has achieved great clinical success and several other ABL inhibitors such as Nilotinib [6], Dasatinib [7], Bosutinib [8] and Ponatinib [9] have been developed to be used as the second line therapy to overcome a variety of the drug resistances induced by either various of point mutations or the chronic drug treatment induced BCR-ABL gene amplification [10]. Here, ABL1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.