The pivotal driving force of the CML is the deregulation of the protein tyrosine kinase ABL1, which get constitutively expressed and activated due to genetic fusion of Abelson (ABL) gene with the chromosome 9 and 22 [t(9;22)(q34;q11)] of the break point cluster region (BCR) gene [2, 3]. This evidence concerns the gene ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive.