Therefore, we first evaluated p300 expression in pancreatic cancer using five established human pancreatic cancer cell lines (PSN1, BXPC3, MIAPaCa2, Hs766T, and Panc1) and eleven pancreatic ductal adenocarcinoma tissue samples from patients who had undergone pancreatic resection. This evidence concerns the gene EP300 and pancreatic ductal adenocarcinoma.