TMPRSS11D and familial pancreatic carcinoma: [13, 21, 22] HAT inhibition by C646 increased the cytotoxic effect of gemcitabine at 96 hours for pancreatic cancer cell lines (Figure 5B) and increased gemcitabine-induced apoptosis was confirmed by western blotting for cleaved Caspase 3 and PARP (Figure 5C).