Furthermore, we also found that several SNPs associated with DNA methylation in adipose tissue overlapped directly or via proxy SNPs to previously reported disease loci of obesity related traits, including CETP and FADS2, which are both known to be associated with total cholesterol, LDL, HDL and triglyceride levels [47] These data support that genetic and epigenetic variation together influence metabolic phenotypes and disease risk in humans. Here, FADS2 is linked to obesity due to melanocortin 4 receptor deficiency.