To understand the increased HIV infection levels in cocaine exposed macrophages, we have analyzed the expression of HIV restriction factors [apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3G (APOBEC3G), Bone Marrow Stromal Cell Antigen 2 (BST2) and Tripartite motif-containing protein 5 (TRIM5) alpha] in these cells. This evidence concerns the gene BST2 and HIV infectious disease.