Results showed that platelet ingestion by HepG2 cells was significantly higher after platelets were co-cultured with CD8+ T cells from ITP patients in the cytotoxic group than CD8+ T cells from the non-cytotoxic group and controls (cytotoxic group vs. non-cytotoxic group: 12.44% ± 3.09% vs. 6.21% ± 2.55%, respectively, P < 0.001; cytotoxic group vs. controls: 12.44% ± 3.09% vs. 4.38% ± 2.44%, respectively, P < 0.001), which could be inhibited by neuraminidase inhibitor DANA (without DANA vs. with DANA, 12.44% ± 3.09% vs. 8.32% ± 2.70%, respectively, P = 0.003, Fig. 3e,f). This evidence concerns the gene CD8A and autoimmune thrombocytopenic purpura.