While our previous studies showed that AKT signalling drives metastasis of PIK3CA mutant tumours39, here we propose the p110α–PDK1–RSK2–ATF4–GPT2 signaling axis reprogrammes glutamine metabolism that is required to generate energy and metabolites to sustain rapid growth in PIK3CA mutant tumours. The gene discussed is PIK3CA; the disease is neoplasm.