Interestingly, previous studies have reported that elevated levels of KIM-1/Cr correlate with the progression from normoalbuminuria to microalbuminuria (14) and that urinary KIM-1/Cr is associated with insulin resistance even prior to the development of diabetes (26), indicating that urinary KIM-1/Cr could be an early marker for diabetic nephropathy. This evidence concerns the gene HAVCR1 and Insulin resistance.