Of note, among sepsis and SIRS patients, the blood levels of CIR-miRNAs inversely correlate with the plasma levels of key pro-inflammatory mediators such as interleukin-(IL)-1, IL-6, IL-8 and C-reactive protein (CRP), previously identified in systemic inflammation and sepsis3, 29. The gene discussed is CXCL8; the disease is Sepsis.