CXCL8 and supranuclear palsy, progressive, 1: However, CIR-miRNA scores negatively correlated with levels of pro-inflammatory mediators, suggesting that a marked increase of multiple CIR-miRNAs is significantly associated with low levels of pro-inflammatory markers (CRP and PSP, Fig. 5B) and cytokines (IL-1, IL-8 and IL-6, Fig. 5C).