EIF4EBP3 and metastatic malignant neoplasm in the lymph nodes: Surprisingly, the frequency of distant metastasis and lymph node metastasis (pN1) was significantly higher in the 4E-BP3 low group (Supplementary Fig. 20), suggesting 4E-BP3 expression level may predict metastatic potential of tumours in addition to mTORC1 activation status.